Dr. Gregory House still has the most unapologetically prickly bedside manner ever, but his genius for solving the medical mysteries other practitioners can't, has earned him the respect of his team. House's unpredictable cases - from killer germs to killer secrets - strain his already tenuous relationship with his co-workers and put his own health at risk.

He's sarcastic, incorrigible, bitter, and in a relationship? Dr. Gregory House has spent his career taking on seemingly hopeless cases, but when his rapport with Dr. Lisa Cuddy changes, he finds himself facing new, and very different, challenges. His team at Princeton-Plainsboro Teaching Hospital also continues to blaze trails as they investigate baffling medical cases involving a religious zealot, a professional bull rider, and possibly even smallpox....